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| 15.03.2017 | CMX | Santos Laguna | 1-3 | Cruz Azul | |
| 13.02.2017 | D1 | Santos Laguna | 2-2 | Cruz Azul | |
| 21.08.2016 | D1 | Cruz Azul | 3-1 | Santos Laguna | |
| 17.04.2016 | D1 | Cruz Azul | 0-1 | Santos Laguna | |
| 24.10.2015 | D1 | Santos Laguna | 1-2 | Cruz Azul | |
| 18.01.2015 | D1 | Cruz Azul | 1-0 | Santos Laguna |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 3 | 2 | 1 | 13 | 7 | 6 |
| away | 6 | 4 | 1 | 1 | 11 | 6 | 5 |
| total | 6 | 4 | 1 | 1 | 11 | 4 | 7 |
| Cruz Azul win | 39.66% | 23 |
| draw | 22.41% | 13 |
| Cruz Azul lose | 37.93% | 22 |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 1 | 1 | 4 | 5 | 11 | -6 |
| away | 6 | 0 | 1 | 5 | 6 | 11 | -5 |
| total | 6 | 1 | 1 | 4 | 5 | 8 | -3 |
| Santos Laguna win | 37.93% | 22 |
| draw | 22.41% | 13 |
| Santos Laguna lose | 39.66% | 23 |
| 01.03.2025 | D1 | Mazatlán FC | 1-1 | Cruz Azul |  |
| 24.02.2025 | D1 | Cruz Azul | 1-0 | Querétaro FC |  |
| 20.02.2025 | D1 | Santos Laguna | 0-1 | Cruz Azul | |
| 16.02.2025 | D1 | Tigres UANL | 2-1 | Cruz Azul |  |
| 12.02.2025 | CCL | Cruz Azul | 5-0 | Real Hope FA | |
| 09.02.2025 | D1 | Cruz Azul | 2-1 | Pachuca CF | |
| 24.02.2025 | D1 | Santos Laguna | 2-0 | Club Atlas | |
| 20.02.2025 | D1 | Santos Laguna | 0-1 | Cruz Azul | |
| 15.02.2025 | D1 | Mazatlán FC | 1-1 | Santos Laguna | |
| 08.02.2025 | D1 | Club Necaxa | 3-2 | Santos Laguna | |
| 03.02.2025 | D1 | Santos Laguna | 0-2 | Club Puebla | |
| 30.01.2025 | D1 | FC Juárez | 1-0 | Santos Laguna | |
| over 2.5 | 54.55% | 18 |
| under 2.5 | 45.45% | 15 |
| over 2.5 | 40.00% | 14 |
| under 2.5 | 60.00% | 21 |
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