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| 06.01.2013 | D1 | San Luis FC | 1-1 | Santos Laguna | |
| 22.07.2012 | D1 | Santos Laguna | 2-1 | San Luis FC | |
| 04.03.2012 | D1 | Santos Laguna | 5-2 | San Luis FC | |
| 18.09.2011 | D1 | San Luis FC | 0-1 | Santos Laguna | |
| 24.04.2011 | D1 | Santos Laguna | 1-3 | San Luis FC | |
| 07.11.2010 | D1 | San Luis FC | 1-1 | Santos Laguna |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 2 | 1 | 3 | 7 | 10 | -3 |
| away | 6 | 0 | 1 | 5 | 6 | 12 | -6 |
| total | 6 | 2 | 1 | 3 | 9 | 10 | -1 |
| Santos Laguna win | 54.16% | 13 |
| draw | 29.17% | 7 |
| Santos Laguna lose | 16.67% | 4 |
| GP | W | D | L | GF | GA | +/- | |
| home | |||||||
| away | |||||||
| total |
| San Luis (Mex) win | 16.66% | 4 |
| draw | 29.17% | 7 |
| San Luis (Mex) lose | 54.17% | 13 |
| 10.03.2025 | D1 | Santos Laguna | 2-1 | Club León |  |
| 03.03.2025 | D1 | CF Monterrey | 4-2 | Santos Laguna |  |
| 24.02.2025 | D1 | Santos Laguna | 2-0 | Club Atlas | |
| 20.02.2025 | D1 | Santos Laguna | 0-1 | Cruz Azul | |
| 15.02.2025 | D1 | Mazatlán FC | 1-1 | Santos Laguna |  |
| 08.02.2025 | D1 | Club Necaxa | 3-2 | Santos Laguna | |
| 05.08.2024 | LC | Orlando City SC | 1-1/p.5-4 | San Luis FC | |
| 31.07.2024 | LC | San Luis FC | 2-3 | CF Montréal | |
| 05.05.2013 | D1 | Deportivo Toluca | 0-1 | San Luis FC | |
| 28.04.2013 | D1 | San Luis FC | 1-0 | Club Tijuana | |
| 21.04.2013 | D1 | Querétaro FC | 2-1 | San Luis FC | |
| 14.04.2013 | D1 | San Luis FC | 2-2 | Club Atlas | |
| over 2.5 | 43.24% | 16 |
| under 2.5 | 56.76% | 21 |
| over 2.5 | % | |
| under 2.5 | % |
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