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United States| 15.09.2021 | LC | Seattle Sounders | 1-0 | Santos Laguna | |
| 10.04.2013 | CCL | Santos Laguna | 1-1 | Seattle Sounders | |
| 03.04.2013 | CCL | Seattle Sounders | 0-1 | Santos Laguna | |
| 15.03.2012 | CCL | Santos Laguna | 6-1 | Seattle Sounders | |
| 08.03.2012 | CCL | Seattle Sounders | 2-1 | Santos Laguna |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 1 | 2 | 3 | 3 | 7 | -4 |
| away | 6 | 0 | 1 | 5 | 5 | 15 | -10 |
| total | 6 | 0 | 2 | 4 | 3 | 11 | -8 |
| Santos Laguna win | 40.00% | 2 |
| draw | 20.00% | 1 |
| Santos Laguna lose | 40.00% | 2 |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 2 | 3 | 1 | 6 | 4 | 2 |
| away | 6 | 4 | 1 | 1 | 12 | 4 | 8 |
| total | 6 | 3 | 3 | 0 | 7 | 2 | 5 |
| SEA Sounders win | 40.00% | 2 |
| draw | 20.00% | 1 |
| SEA Sounders lose | 40.00% | 2 |
| 09.11.2024 | D1 | Querétaro FC | 3-2 | Santos Laguna |  |
| 06.11.2024 | D1 | Santos Laguna | 0-2 | Guadalajara Chivas | |
| 03.11.2024 | D1 | Cruz Azul | 2-0 | Santos Laguna | |
| 26.10.2024 | D1 | Santos Laguna | 0-0 | Mazatlán FC |  |
| 23.10.2024 | D1 | Santos Laguna | 1-1 | Pachuca CF | |
| 20.10.2024 | D1 | Club América | 3-0 | Santos Laguna | |
| 04.11.2024 | P/O | Houston Dynamo | 1-1/p.6-7 | Seattle Sounders | |
| 29.10.2024 | P/O | Seattle Sounders | 0-0/p.5-4 | Houston Dynamo | |
| 20.10.2024 | D1 | Seattle Sounders | 1-1 | Portland Timbers | |
| 06.10.2024 | D1 | Colorado Rapids | 0-1 | Seattle Sounders |  |
| 03.10.2024 | D1 | Vancouver WC | 0-3 | Seattle Sounders | |
| 29.09.2024 | D1 | Seattle Sounders | 1-0 | Houston Dynamo | |
| over 2.5 | 39.29% | 11 |
| under 2.5 | 60.71% | 17 |
| over 2.5 | 54.00% | 27 |
| under 2.5 | 46.00% | 23 |
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