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| 19.03.2022 | D1 | Club Puebla | 2-2 | Santos Laguna | |
| 20.09.2021 | D1 | Santos Laguna | 1-1 | Club Puebla | |
| 24.05.2021 | D1PO | Club Puebla | 1-0 | Santos Laguna | |
| 21.05.2021 | D1PO | Santos Laguna | 3-0 | Club Puebla | |
| 03.05.2021 | D1 | Santos Laguna | 0-0 | Club Puebla | |
| 03.10.2020 | D1 | Club Puebla | 0-2 | Santos Laguna |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 1 | 1 | 4 | 4 | 9 | -5 |
| away | 6 | 0 | 0 | 6 | 3 | 11 | -8 |
| total | 6 | 0 | 1 | 5 | 0 | 8 | -8 |
| Puebla win | 18.00% | 9 |
| draw | 40.00% | 20 |
| Puebla lose | 42.00% | 21 |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 2 | 0 | 4 | 7 | 11 | -4 |
| away | 6 | 0 | 1 | 5 | 6 | 15 | -9 |
| total | 6 | 0 | 0 | 6 | 4 | 16 | -12 |
| Santos Laguna win | 42.00% | 21 |
| draw | 40.00% | 20 |
| Santos Laguna lose | 18.00% | 9 |
| 19.04.2025 | D1 | Club Puebla | 0-1 | Club Necaxa |  |
| 16.04.2025 | D1 | Guadalajara Chivas | 1-0 | Club Puebla | |
| 13.04.2025 | D1 | Club León | 1-0 | Club Puebla | |
| 05.04.2025 | D1 | Club Puebla | 0-0 | Tigres UANL |  |
| 30.03.2025 | D1 | FC Juárez | 2-0 | Club Puebla | |
| 15.03.2025 | D1 | Club Puebla | 0-3 | Deportivo Toluca | |
| 21.04.2025 | D1 | Santos Laguna | 0-4 | Club Tijuana | |
| 17.04.2025 | D1 | UNAM Pumas | 2-0 | Santos Laguna | |
| 14.04.2025 | D1 | Santos Laguna | 1-2 | Querétaro FC | |
| 07.04.2025 | D1 | Deportivo Toluca | 2-1 | Santos Laguna | |
| 31.03.2025 | D1 | Santos Laguna | 2-3 | Atlético San Luis | |
| 16.03.2025 | D1 | Tigres UANL | 3-0 | Santos Laguna | |
| over 2.5 | 41.03% | 16 |
| under 2.5 | 58.97% | 23 |
| over 2.5 | 48.84% | 21 |
| under 2.5 | 51.16% | 22 |
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